Although I'm not an evolutionary biologist, I contend that since life's inception on Earth - estimated between 3.5 to 4.5 billion years ago - no species has ever experienced the level of evolutionary pressure that humans presently face. Our way of life has significantly diverged from what our biology was initially designed to handle.
The human body evolved over millions of years for a lifestyle vastly different from today's routines. We did not evolve to:
Spend our days glued to computer screens or toil away on assembly lines,
Consume the processed, nutrient-depleted foods that fill our modern diets,
Engage with and depend on complex technologies,
Clothe ourselves, thus altering our body's natural thermoregulation,
Reside in densely populated urban landscapes, far removed from nature,
Rely on constant medical intervention.
Most of these drastic lifestyle changes have occurred within the past 400 years. From an evolutionary perspective, this period is a mere blink of an eye. Each of these adaptations to our habits and environments exerts considerable pressure on our genes, nudging them towards evolutionary pathways we cannot fully predict.
Given the multitude of evolutionary forces currently in motion, it seems plausible to posit that humanity will undergo significant transformations. Perhaps, in just 10-20 generations, humans may begin to look and function very differently. It's entirely possible that a human from 500 years hence may bear less resemblance to us than we do to our ancestors who lived half a millennium ago.